During liver radioembolization, radionuclides are applied selectively to the liver by a transarterial catheter. The radionuclides irradiate tumor tissue and the liver itself. In order to plan the delivery of radiation, internal dosimetry is performed. It is an essential step for successful radioembolization.
SIRTOP aims at developing novel approaches for radioembolization dosimetry. This includes methods that allow to determine the amount of activity that has to be delivered to the patient as well as methods to calculate the absorbed dose inside normal liver and tumor tissue. Advanced internal dosimetry and optimization of dose delivery allow for patient-individual, three-dimensional dose distributions.